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EC number: 222-294-1 | CAS number: 3407-42-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to fish, other
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Data is from computational model developed by USEPA
- Qualifier:
- according to guideline
- Guideline:
- other: Modeling database
- Principles of method if other than guideline:
- Long term toxicity study of test chemical were studied on the mortality rate of fish.
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- other: Fish
- Test type:
- flow-through
- Water media type:
- saltwater
- Total exposure duration:
- 28 d
- Test temperature:
- 25 Deg.C
- Reference substance (positive control):
- no
- Key result
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.164 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: Neutral Organics
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Based on the EPI Suite ECOSAR, the 28 d NOEC value was estimated to be 0.164 mg/l on Fish for test substance on the basis of no mortality effects.
- Executive summary:
Using the EPI Suite ECOSAR, the long term toxicity on fish was predicted for test substance. On the basis of no effects observed in a flow-through system, the no observed effect concentration (NOEC) value for the substance is estimated to be 0.164 mg/l for saltwater fish for 28 d duration. Thus on the basis of NOEC value, chemical consider to be toxic and classified in aquatic chronic category 2 as per the CLP classification criteria.
Reference
Description of key information
Using the EPI Suite ECOSAR, the long term toxicity on fish was predicted for test substance. On the basis of no effects observed in a flow-through system, the no observed effect concentration (NOEC) value for the substance is estimated to be 0.164 mg/l for saltwater fish for 28 d duration. Thus on the basis of NOEC value, chemical consider to be toxic and classified in aquatic chronic category 2 as per the CLP classification criteria.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.164 mg/L
Additional information
Various experimental and predicted studies available for the test chemical and functionally similar read across chemical were reviewed to determine the toxic nature of test chemical on the fish. The studies are as mentioned below:
Using the EPI Suite ECOSAR, the long term toxicity on fish was predicted for test substance. On the basis of no effects observed in a flow-through system, the no observed effect concentration (NOEC) value for the substance is estimated to be 0.164 mg/l for saltwater fish for 28 d duration. Thus on the basis of NOEC value, chemical consider to be toxic and classified in aquatic chronic category 2 as per the CLP classification criteria.
Above data was supported by the second study from authoritative database. Aim of this study was to determine the prolonged effect of test chemical on the freshwater fish. Test conducted for 14 days under semi-static system. After the exposure of test chemical with fish for 14 days, LC50 was determine at 0.78 mg/l and no effect (NOEC) were observed at 0.14 mg/l. Thus based on the LC50 value, chemical consider to be toxic and classified as aquatic chronic 2 as per the CLP classification criteria.
Objective of this third study was to determine the prolonged effect of test chemical on the fish by providing the exposure period of 14 days. After the exposure of chemical with fish for 14 days, no effect (NOEC) were observed on fish at concentration 0.75 mg/l and LC50 at the 2.3 mg/l. Thus on the basis of NOEC value, chemical consider to be toxic and classified as aquatic chronic 2 as per the CLP classification criteria.
Thus by considering the above effects, chemical consider to be toxic and classified as aquatic chronic 2 as per the CLP classification criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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