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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Dissociation constant

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Administrative data

Link to relevant study record(s)

Description of key information

pKa = 8.05 at 25 °C

Key value for chemical safety assessment

Additional information

The dissociation constant of 4'-hydroxyacetophenone was reported in an authoritative secondary source to be pKa = 8.05 at 25 °C. This attribute was supported by accepted calculation methods with a result of pKa = 8.05 at 25 °C in the SRC PhysProp database respectiveley 8.08 in a Sparc v4.5 calculation. Thus a dissociation constant of 8.05 at 25 °C is regarded to be reliable for 4'-hydroxyacetophenone.