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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: basic information given

Data source

Reference
Reference Type:
publication
Title:
Hydroxyacetophenones: Urinary metabolites of ethylbenzene and acetophenone in the rabbit.
Author:
Kiese, M., Lenk, W.
Year:
1974
Bibliographic source:
Xenobiotica 4(6), 37 - 343

Materials and methods

Objective of study:
metabolism
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethylbenzene
EC Number:
202-849-4
EC Name:
Ethylbenzene
Cas Number:
100-41-4
Molecular formula:
C8H10
IUPAC Name:
ethylbenzene

Test animals

Species:
rabbit
Strain:
not specified
Sex:
male
Details on test animals or test system and environmental conditions:
Male rabbits, weighing 3.8 to 4.3 kg, were housed individually in metabolic cages and fed Altromin standard diet and water ad libitum.

Administration / exposure

Route of administration:
intraperitoneal
Doses / concentrations
Remarks:
Doses / Concentrations:
In two experiments with 5 male rabbits each and a total intraperitoneal dose of 4.45 g of undistilled ethylbenzene as well as in three experiments with 5 male rabbits each and a total intraperitoneal dose of 5.36 g of undistilled acetophenone urine was collected for 48 hours.
No. of animals per sex per dose / concentration:
5

Results and discussion

Any other information on results incl. tables

The results of the present investigation on rabbits add omega, p- and m-hydroxyacetophenone to the known metabolites of acetophenone and ethylbenzene. According to the authours, the small amounts of these metabolites found in the urine would classify them as "minor metabolites".

Applicant's summary and conclusion

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