Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Additional information:

4 -Hydroxyacetophenone was tested in a guinea pig maximization test (UBTL Inc., 1992) with an intradermal injection (as a 5% solution in propylene glycol with and without Freund's adjuvant) and then by a topical application (5% in propylene glycol) eight days later. Two weeks after the second induction, animals were challenged with 0.5 g of test material as a 75% preparation in petrolatum using a 24-h dermal exposure. No sensitizing properties were found.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Based on the available data, classification is not warranted according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.