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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1970
Report date:
1970

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Amines, C11-C13 (linear and branched) alkyl
EC Number:
701-381-2
IUPAC Name:
Amines, C11-C13 (linear and branched) alkyl
Details on test material:
- Tridecylamine technical grade
- Purity approx. 95%

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 3.2 kg

Test system

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
TEST MATERIAL
- Amount applied: approx. 0.5 ml
- Concentration: undiluted
Duration of treatment / exposure:
Dorsal skin: 1, 5, 15 minutes and 20 hours
Ear: 20 hours
Observation period:
8 days
Number of animals:
2
Details on study design:
TEST SITE
- Area of exposure: Dorsal skin and ear

REMOVAL OF TEST SUBSTANCE
- Washing: Lutrol 50%

SCORING SYSTEM:
- similar to the table contained in OECD TG 404

Results and discussion

In vivo

Results
Time point:
48 h
Reversibility:
not reversible
Remarks on result:
other: necrosis

Any other information on results incl. tables

Skin reactions:

After removal of the test substance, bleeding in the skin was observed after 1, 5, 15min exposure.

Time of exposure

Findings after 24 h

Findings after 8 days

Dorsal skin

1 min

N+

N+/ N++ margin: ER++/ED++

5 min

N+

N++/margin: ER++/ED++

15 min

N+

N++/margin: ER++/ED++

20 h

N+/margin: ER++/ED++

N++/margin: ER++/ED++

Ear

20 h

N+++

Mummification

N = necrosis; ER = erythema; ED = edema; Ø = nonirritating; (+) = slight; + = distinct; ++ = severe; +++ = very severe

Applicant's summary and conclusion

Interpretation of results:
Category 1B (corrosive) based on GHS criteria
Conclusions:
Skin necrosis was seen 48 hours after contact to tridecylamine for 1 (1 out of 2 animals), 5 or 15 minutes or 20 hours.