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Fowler and coworkers (1976) showed that aliphatic amines including Tridecylamine injected into mice tended to concentrate in lung tissue. Lung uptake of Tridecylamine at 1 minute after injection was ca. 13.5 % of the administered dose. The authors reported that the amino group and a relatively lipophilic alkyl group were required for lung specificity. It was also shown that the radiolabeled amines were rapidly metabolized. Tridecylamine had the longest carbon chain of the tested series of amines. Liberation of carbon dioxide from injected Tridecylamine was relatively slow. It was only ca. 14 % of the injected dose at 20 min post injection. At the same time point CO2-excretion of the alkyl amines C4 to C10 amounted to more than 40 % of the dose, and exceeded 50 % in the case of C6 and C7 alkylamines. Pretreatment with inhibitors of Monoamine Oxidases (MAO) significantly increased the radioactivity retained by the brain, lungs, and liver. The rate of CO2-excretion depended on the carbon chain length.