Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
no data
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,5-naphthylene diisocyanate
EC Number:
221-641-4
EC Name:
1,5-naphthylene diisocyanate
Cas Number:
3173-72-6
Molecular formula:
C12H6N2O2
IUPAC Name:
1,5-diisocyanatonaphthalene
Constituent 2
Reference substance name:
Desmodur 15
IUPAC Name:
Desmodur 15
Details on test material:
- Name of test material (as cited in study report): 1,5-Naphthylendiisocyanat (Desmodur 15)
- Physical state: solid
- Purity: 99.8 %

Test animals

Species:
rat
Strain:
Wistar
Sex:
female
Details on test animals or test system and environmental conditions:
TEST ANIMALS:
- Source: Winkelmann (Borchen, Germany)
- Weight at study initiation: 120-140 g

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
water
Details on exposure:
no data
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Statistics:
no data

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw

Applicant's summary and conclusion