Registration Dossier
Registration Dossier
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EC number: 221-641-4 | CAS number: 3173-72-6
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity to fish:
Short-term toxicity of 1,5 -naphthylene diisocyanate to fish (Danio rerio) was determined according to EU method C.1 which is in most parts equivalent to OECD 203 and is given as 96 hour-LL50 > 100 mg/L (LL = Lethal Loading), related to nominal concentrations (Bayer Industry Services, 2005).
Short-term toxicity to aquatic invertebrates:
Short-term toxictiy of 1,5 -naphthylene diisocyanate to invertebrates (Dapnia magna) was determined according to EU method C.2 which is in most parts equivalent to OECD 202 and is given as 48 hours-EL50 > 100 mg/L (EL = Effective Loading), related to nominal concentrations (Bayer Industry Services, 2005).
Toxicity to algae and cyanobacteria:
Toxicity of1,5-naphthalene diisocyanateto aquatic algae(Desmodesmus subspicatus) was determined according to EU method C.3 which is in most parts equivalent to OECD 203 as is given as 72 hour-ErC50 = 8.74 mg/L, related to geometric meanmeasured concentrations. 72 hour-EC10, based on growth rate,is given as 0.512 mg/L (Bayer Industry Services, 2006)
Toxicity to microorganisms:
Toxicity of 1,5 -naphthalene diisocyanate to microorganisms was determined with activated sludge according to Directive 88/302/EEC which is in most parts equivalent to OECD 209 and is given as 3 hour-EC50 > 10,000 mg/L, related to nominal concentration (Bayer Industry Services 2005).
As the parent compound1,5-naphthylene diisocyanate hydrolyses to the main hydrolysis product 1,5-naphthylene diamine
within less than 1 hour the parent compound is factually non-existent under environmental or laboratory conditions in aquatic media.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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