Registration Dossier
Registration Dossier
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EC number: 221-641-4 | CAS number: 3173-72-6
Endpoint summary
Administrative data
Description of key information
Additional information
1,5-naphthylene diisocyanate (parent compound):
Based on a calculated log Kow of 4.37 (EPI Suite program v3.20) a bioconcentration factor BCF of about 460 is estimated (EPI Suite program v3.20) for the parent compound 1,5-naphthylene diisocyanate, indicating that non-hydrolysed 1,5-naphthylene diisocyanate might have a potential for bioconcentration (Currenta 2010).As 1,5-naphthylene diisocyanate hydrolyses very rapidly in aquatic media with a half life time of less than 1 hour the estimated BCF is only of theoretical interest.
1,5-diaminonaphthalene (environmental relevant degradation compound in water and sediment):
The bioconcentration factor (BCF) of 1,5-diaminonaphthalene in carp (Cyprinus carpio) was determined by the Chemicals Inspection & Testing Institute of Japan (MITI, 1992). The test was conducted in accordance with “Bioaccumulation test of chemical substance in fish and shellfish stipulated in the Order Prescribing the Items of the Test Relating to the New Chemical Substance” (1974). This guideline corresponds to the OECD TG 305C, “Bioaccumulation: Degree of bioconcentration in fish”.
The fish were exposed to concentrations of 0.2 mg/l and 0.02 mg/l. The BCF was determined by calculation from the kinetics of the uptake and depuration phase of the substance. A BCF of < 4.5 at the low concentration and a BCF of < 0.4 – 1.5 at the higher concentration were obtained. These values indicate that 1,5-diaminonaphthalene has a low potential to bioaccumulate in aquatic organisms.
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