Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-059-9 | CAS number: 628-89-7
Endpoint summary
Administrative data
Description of key information
The chemical 2-(2-chloroethoxy)ethanol was found to be non toxic by any of the route.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from SAX and RTECS
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 6 300 other: mg/kg
- Based on:
- test mat.
- Remarks on result:
- other: Details of toxic effects not reported other than lethal dose value
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- This value suggest that the chemical 2-(2-chloroethoxy)ethanol does not exhibit acute toxicity through the oral route
- Executive summary:
Acute oral toxicity value of 2-(2-chloroethoxy)ethanol in rat was found to be LD50 :6300 mg/kg. This value suggests that the chemical 2-(2-chloroethoxy)ethanol does not exhibit acute toxicity through the oral route for classification as for classification the lethal dose should be less than 2000 mg/kg.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 6 300 mg/kg bw
- Quality of whole database:
- K2 data from relaible handbook SAX
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: estimated data
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 2.3
- GLP compliance:
- no
- Test type:
- other: Acute Rodent Inhalation Toxicity Test
- Species:
- rat
- Strain:
- Long-Evans
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- 8 h
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 133.4 other: mg/l
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The 8h acute inhalation median lethal concentration (LC50) of 2-(2-chloroethoxy)ethanol in rat was estimated to be 133.4001 mg/L. This value indicates that 2-(2-chloroethoxy)ethanol does not exhibits acute toxicity by the inhalative route
- Executive summary:
</font> The 8h acute inhalation median lethal concentration (LC50) of 2-(2-chloroethoxy)ethanol in rat was estimated to be 133.4001 mg/L . This value indicates that 2-(2-chloroethoxy)ethanol does not exhibits acute toxicity by the inhalative route. In order to classify the substance in inhalation category the lethal dose should be in the range of less than 20 mg/L in vapour condition.
Reference
The prediction was based on dataset comprised from the following descriptors: LC50
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(("a" and "b" ) and ("c" and "d" ) )
Domain logical expression index: "a"
Similarity boundary:Target: C(Cl)COCCO
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Similarity boundary:Target: C(Cl)COCCO
Threshold=60%,
Dice(Atom pairs)
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is >= -0.529
Domain logical expression index: "d"
Parametric boundary:The target chemical should have a value of log Kow which is <= 0.516
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 133.4 mg/m³ air
- Quality of whole database:
- K2 data from QSAR model considered reliable by OECD
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from SAX
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: other details not available
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Acute dermal toxicity (LD50) of 2-(2-chloroethoxy)ethanol in guinea pig was found to be 3000 mg/Kg. This value indicates that 2-(2-chloroethoxy)ethanol is not toxic to skin of guinea pig
- Executive summary:
Acute dermal toxicity (LD50) of 2-(2-chloroethoxy)ethanol in guinea pig was found to be 3000 mg/Kg. This value suggests that 2-(2-chloroethoxy) ethanol is not toxic to skin of guinea pig. In order to classify the substance in dermal category the lethal dose should be in the range of less than 2000 mg/kg in normal condition.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 000 mg/kg bw
- Quality of whole database:
- K2 data from relaible handbook SAX
Additional information
Acute Toxicity :
Acute toxicity : Oral
Acute oral toxicity value of 2-(2-chloroethoxy)ethanol in rat was found to be LD50 :6300 mg/kg. This value suggest that the chemical 2-(2-chloroethoxy)ethanol does not exhibit acute toxicity through the oral route
Acute toxicity : Inhalation
The 8h acute inhalation median lethal concentration (LC50) of 2-(2-chloroethoxy)ethanol in rat was estimated to be 133.4001 mg/L. This value indicates that 2-(2-chloroethoxy)ethanol does not exhibits acute toxicity by the inhalative route
No of studies reviewed for Acute toxicity: inhalation from reliable sources having Klimish rating 2
The summary if the results are presented below
Sr. No |
Endpoint name |
Value |
Units |
Species |
1 |
LC50 | 133.4001 | mg/l | Rat |
| 2 | LC50 | 70.87939 | mg/l | Mouse |
Based on the above endpoint values it can be concluded that the substance is classified as non toxic based on classification criteria .
Acute toxicity : Dermal
Acute dermal toxicity (LD50) of 2-(2-chloroethoxy)ethanol in guinea pig was found to be 3000 mg/Kg. This value indicates that 2-(2-chloroethoxy)ethanol is not toxic to skin of guinea pig
Justification for selection of acute toxicity – oral endpoint
Acute oral toxicity value of 2-(2-chloroethoxy)ethanol in rat was found to be LD50 :6300 mg/kg. This value suggests that the chemical 2-(2-chloroethoxy)ethanol does not exhibit acute toxicity through the oral route for classification as for classification the lethal dose should be less than 2000 mg/kg.
Justification for selection of acute toxicity – inhalation endpoint
The 8h acute inhalation median lethal concentration (LC50) of 2-(2-chloroethoxy)ethanol in rat was estimated to be 133.4001 mg/L . This value indicates that 2-(2-chloroethoxy)ethanol does not exhibits acute toxicity by the inhalative route. In order to classify the substance in inhalation category the lethal dose should be in the range of less than 20 mg/L in vapour condition.
Justification for selection of acute toxicity – dermal endpoint
Acute dermal toxicity (LD50) of 2-(2-chloroethoxy)ethanol in guinea pig was found to be 3000 mg/Kg. This value suggests that 2-(2-chloroethoxy) ethanol is not toxic to skin of guinea pig. In order to classify the substance in dermal category the lethal dose should be in the range of less than 2000 mg/kg in normal condition.
Justification for classification or non-classification
The available studies indicate that 2-(2-chloroethoxy)ethanol is not classified as a acute toxicity by any of the route (oral, dermal and inhalation), according to the C & L regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
