2-(2-chloroethoxy)ethanol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Justification for type of information:

QSAR prediction: migrated from IUCLID 5.6

Data source

Reference

Reference Type:

other: Predicted data

Title:

R: QSAR Toolbox 2.3.0.1132 prediction for LC50 read across evaluation for 628-89-7

Author:

Sustainability Support Services (Europe) AB

Year:

2012

Bibliographic source:

QSAR Toolbox version 2.3

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: estimated data

Principles of method if other than guideline:

Prediction is done using QSAR Toolbox version 2.3

GLP compliance:

no

Test type:

other: Acute Rodent Inhalation Toxicity Test

Test material

Test material information

Constituent 1

Reference substance name:

2-(2-chloroethoxy)ethanol

EC Number:

211-059-9

EC Name:

2-(2-chloroethoxy)ethanol

Cas Number:

628-89-7

Molecular formula:

C4H9ClO2

IUPAC Name:

2-(2-chloroethoxy)ethan-1-ol

Details on test material:

- Name of test material : 2-(2-chloroethoxy)ethanol
- Molecular formula : C4H9ClO2
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:

rat

Strain:

Long-Evans

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

not specified

Duration of exposure:

8 h

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LC50

Effect level:

133.4 other: mg/l

Based on:

test mat.

Exp. duration:

8 h

Any other information on results incl. tables

The prediction was based on dataset comprised from the following descriptors: LC50
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain

(("a" and "b" ) and ("c" and "d" ) )

Domain logical expression index: "a"

Similarity boundary:Target: C(Cl)COCCO
Threshold=50%,
Dice(Atom pairs)

Domain logical expression index: "b"

Similarity boundary:Target: C(Cl)COCCO
Threshold=60%,
Dice(Atom pairs)

Domain logical expression index: "c"

Parametric boundary:The target chemical should have a value of log Kow which is >= -0.529

Domain logical expression index: "d"

Parametric boundary:The target chemical should have a value of log Kow which is <= 0.516

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The 8h acute inhalation median lethal concentration (LC50) of 2-(2-chloroethoxy)ethanol in rat was estimated to be 133.4001 mg/L. This value indicates that 2-(2-chloroethoxy)ethanol does not exhibits acute toxicity by the inhalative route

Executive summary:

The 8h acute inhalation median lethal concentration (LC50) of 2-(2-chloroethoxy)ethanol in rat was estimated to be 133.4001 mg/L . This value indicates that 2-(2-chloroethoxy)ethanol does not exhibits acute toxicity by the inhalative route. In order to classify the substance in inhalation category the lethal dose should be in the range of less than 20 mg/L in vapour condition.

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