Registration Dossier
Registration Dossier
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EC number: 211-059-9 | CAS number: 628-89-7
Toxicity to reproduction
Administrative data
- Endpoint:
- two-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: Predicted data
- Title:
- R: QSAR Toolbox 3.0.1132 prediction for LOEL read across evaluation for for 628-89-7
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 012
- Bibliographic source:
- QSAR Toolbox version 3
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: National Toxicology Programme Continuous Breeding Protocol
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 2.3.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-(2-chloroethoxy)ethanol
- EC Number:
- 211-059-9
- EC Name:
- 2-(2-chloroethoxy)ethanol
- Cas Number:
- 628-89-7
- Molecular formula:
- C4H9ClO2
- IUPAC Name:
- 2-(2-chloroethoxy)ethan-1-ol
- Details on test material:
- - Name of test material : 2-(2-chloroethoxy)ethanol
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
Administration / exposure
- Route of administration:
- oral: drinking water
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- not specified
- Control animals:
- not specified
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- NOAEL
- Effect level:
- 1 526.667 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: not specified
- Remarks on result:
- other: Generation: fertility;P;F2 (migrated information)
Target system / organ toxicity (P0)
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
Results: F2 generation
Effect levels (F2)
- Remarks on result:
- not measured/tested
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
- Treatment related:
- not specified
Any other information on results incl. tables
The
prediction was based on dataset comprised from the following
descriptors: NOAEL
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((("a"
and "b" )
and "c" )
and ("d"
and "e" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Nonionic Surfactants by US-EPA
New Chemical Categories
Domain
logical expression index: "b"
Similarity
boundary:Target:
C(Cl)COCCO
Threshold=50%,
Dice(Atom centered fragments)
Domain
logical expression index: "c"
Similarity
boundary:Target:
C(Cl)COCCO
Threshold=50%,
Dice(Atom centered fragments)
Domain
logical expression index: "d"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= -1.48
Domain
logical expression index: "e"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 0.569
Applicant's summary and conclusion
- Conclusions:
- The two generation reproductive toxicity NOAEL (No observed adverse effect level) of 2-(2-chloroethoxy)ethanol in mouse(CD-1) by the oral route was observed at a dose concentration of 1526.666625977 mg/kgbw/day.
- Executive summary:
The two generation reproductive toxicity NOAEL (No observed adverse effect level) of 2-(2-chloroethoxy)ethanol in mouse(CD-1) by the oral route was estimated at a dose concentration of 1526.666625977 mg/kgbw/day. The estimation study inferes that no effect level has been observed for this substance and so 2-(2-chloroethoxy)ethanol will not have any impact on the reproductive toxicity of the species.
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