2-(2-chloroethoxy)ethanol

Repeated dose toxicity: oral

Administrative data

Endpoint:

short-term repeated dose toxicity: oral

Type of information:

(Q)SAR

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Justification for type of information:

QSAR prediction: migrated from IUCLID 5.6

Data source

Reference

Reference Type:

other: Predicted data

Title:

R: QSAR Toolbox 2.3.0.1132 prediction for "Effect LOEL" read across evaluation for 628-89-7

Author:

Sustainability Support Services (Europe) AB

Year:

2012

Bibliographic source:

QSAR Toolbox version 2.3

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: estimated data

Principles of method if other than guideline:

Prediction is done using QSAR Toolbox version 2.3.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-(2-chloroethoxy)ethanol

EC Number:

211-059-9

EC Name:

2-(2-chloroethoxy)ethanol

Cas Number:

628-89-7

Molecular formula:

C4H9ClO2

IUPAC Name:

2-(2-chloroethoxy)ethan-1-ol

Details on test material:

- Name of test material : 2-(2-chloroethoxy)ethanol
- Molecular formula : C4H9ClO2
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:

rat

Strain:

other: F344/N;F344/DuCrj;Osborne-Mendel;Sherman;Sprague-Dawley

Sex:

not specified

Administration / exposure

Route of administration:

other: no data

Vehicle:

not specified

Analytical verification of doses or concentrations:

not specified

Results and discussion

Effect levels

Dose descriptor:

LOEL

Effect level:

602.266 mg/kg bw/day (nominal)

Based on:

test mat.

Sex:

not specified

Target system / organ toxicity

Critical effects observed:

not specified

Any other information on results incl. tables

The prediction was based on dataset comprised from the following descriptors: "effect LOEL"
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain

(("a" and "b" ) and ("c" and "d" ) )

Domain logical expression index: "a"

Similarity boundary:Target: C(Cl)COCCO
Threshold=50%,
Dice(Atom pairs)

Domain logical expression index: "b"

Similarity boundary:Target: C(Cl)COCCO
Threshold=60%,
Dice(Atom pairs)

Domain logical expression index: "c"

Parametric boundary:The target chemical should have a value of log Kow which is >= -0.908

Domain logical expression index: "d"

Parametric boundary:The target chemical should have a value of log Kow which is <= 0.568

Applicant's summary and conclusion

Conclusions:

This indicates that 2-(2-chloroethoxy)ethanol shall not exhibit toxic effect to rat by the oral route below the above mention dose.

Executive summary:

The repeated dose toxicity LOEL (Lowest observed effect level) of 2-(2-chloroethoxy)ethanol in rat was observed at a dose concentration of 602.2664 mg/kg/day by the oral route.This indicates that 2-(2-chloroethoxy)ethanol shall not exhibit toxic effect to rat by the oral route below the above mention dose.

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