Registration Dossier
Registration Dossier
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EC number: 203-875-9 | CAS number: 111-49-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1985
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature available.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 985
- Reference Type:
- secondary source
- Title:
- Revised Summaries
- Author:
- Invista S.à.r.I.
- Year:
- 2 009
- Bibliographic source:
- US EPA High production volume (HPV) Challenge Program, 2009; http://www.epa.gov/chemrtk/pubs/summaries/hexmthln/c13912tc.htm
Materials and methods
- Principles of method if other than guideline:
- Acute dermal toxicity test
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Perhydroazepine
- EC Number:
- 203-875-9
- EC Name:
- Perhydroazepine
- Cas Number:
- 111-49-9
- Molecular formula:
- C6H13N
- IUPAC Name:
- azepane
- Details on test material:
- - Name of test material (as cited in study report): Hexamethyleneimine
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): wiped gently - Duration of exposure:
- 24 h
- Doses:
- 200 mg/kg bw
- No. of animals per sex per dose:
- 6 animals, sex not indicated
- Control animals:
- not required
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 200 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 1/6 animals died
- Mortality:
- 1/6 animals died 8-14 days after dosing.
Any other information on results incl. tables
Necropsy performed showed mucoid enteropathy in the animals that died (therefore the death observed is thought to be not treatment related as mucoid enteropathy can be attributed to stress of one sort or another, especially change of diet and environment, and conditions causing the rabbit to stop eating such as pain).
Applicant's summary and conclusion
- Conclusions:
- Under the applied test conditions the LD50 value in rabbits is higher than 200 mg/kg bw (i.e. highes dose tested).
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