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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1985
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature available.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Unnamed
Year:
1985
Reference Type:
secondary source
Title:
Revised Summaries
Author:
Invista S.à.r.I.
Year:
2009
Bibliographic source:
US EPA High production volume (HPV) Challenge Program, 2009; http://www.epa.gov/chemrtk/pubs/summaries/hexmthln/c13912tc.htm

Materials and methods

Principles of method if other than guideline:
Acute dermal toxicity test
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Perhydroazepine
EC Number:
203-875-9
EC Name:
Perhydroazepine
Cas Number:
111-49-9
Molecular formula:
C6H13N
IUPAC Name:
azepane
Details on test material:
- Name of test material (as cited in study report): Hexamethyleneimine

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): wiped gently
Duration of exposure:
24 h
Doses:
200 mg/kg bw
No. of animals per sex per dose:
6 animals, sex not indicated
Control animals:
not required

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 200 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 1/6 animals died
Mortality:
1/6 animals died 8-14 days after dosing.

Any other information on results incl. tables

Necropsy performed showed mucoid enteropathy in the animals that died (therefore the death observed is thought to be not treatment related as mucoid enteropathy can be attributed to stress of one sort or another, especially change of diet and environment, and conditions causing the rabbit to stop eating such as pain).

Applicant's summary and conclusion

Conclusions:
Under the applied test conditions the LD50 value in rabbits is higher than 200 mg/kg bw (i.e. highes dose tested).