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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1974
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Principles of method if other than guideline:
Acute oral toxicity test
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Perhydroazepine
EC Number:
203-875-9
EC Name:
Perhydroazepine
Cas Number:
111-49-9
Molecular formula:
C6H13N
IUPAC Name:
azepane
Details on test material:
- Name of test material (as cited in study report): Hexamethylenimine (HMI)
- Composition of test material, percentage of components: 98.18 %
- Lot/batch No.: Haskell No. 8588

Test animals

Species:
rat
Strain:
other: ChR-CD
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
300, 450, 670, 1000, 1500, 2250, 3400 mg/kg
No. of animals per sex per dose:
1 male per dose group
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LDLo
Effect level:
1 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Conclusions:
Under the applied test conditions the test substance has an LD-low value of 1000 mg/kg bw.