Registration Dossier
Registration Dossier
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EC number: 203-875-9 | CAS number: 111-49-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
- Principles of method if other than guideline:
- Acute oral toxicity test
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Perhydroazepine
- EC Number:
- 203-875-9
- EC Name:
- Perhydroazepine
- Cas Number:
- 111-49-9
- Molecular formula:
- C6H13N
- IUPAC Name:
- azepane
- Details on test material:
- - Name of test material (as cited in study report): Hexamethylenimine (HMI)
- Composition of test material, percentage of components: 98.18 %
- Lot/batch No.: Haskell No. 8588
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: ChR-CD
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 300, 450, 670, 1000, 1500, 2250, 3400 mg/kg
- No. of animals per sex per dose:
- 1 male per dose group
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LDLo
- Effect level:
- 1 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Conclusions:
- Under the applied test conditions the test substance has an LD-low value of 1000 mg/kg bw.
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