Registration Dossier
Registration Dossier
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EC number: 203-875-9 | CAS number: 111-49-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No signs of toxicity observed up to limit concentration of 100 mg/L.
NOEC (96h) = 100 mg/L
LC50 (96h) > 100 mg/L
Key value for chemical safety assessment
Additional information
In an acute toxicity test with Rainbow trout (reliability category 1) performed as a limit test at 100 mg/L (measured, flow through), no signes of toxicity were observed in accordance with the results of a range finding test: NOEC (96h) = 100 mg/L (measured) LC50 (96h) > 100 mg/L (measured). The study was based on the ISO International Standard 7346-3: Flow-through method, 1996. In addition, the procedures were designed to meet the test methods and validity criteria of the EEC directive 92/69, Part C.1, 1992 and the OECD guideline No. 203, 1992. The study was performed compliant to GLP.
In a fish embry toxicity test (reliability category 2) performed similar to an OECD draft guideline ("Fish Embryo Toxicity (FET) Test", May 30, 2006 (1st Version) proposed to constitute an alternative test method to the acute toxicity tests (OECD 203), the follwing effect concentration of the test item was determined:
LC50 (48h) = 115.3 mg/L (105.9-125.5).
As no pH adjustment had been performed, pH-related effect at this concentraton cannot be excluded. In any case, observed LC50 (48h) is above 100 mg/L thus corroborating the results of toe OECD 203 test described above.
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