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EC number: 433-260-2 | CAS number: -
In a study according to OECD TG 404 the test item was applied for 4 hours under semiocclusive dressings to the intact shaved skin of 3 male rabbits. Skin irritation was assessed after 1, 24, 48, and 72 hours using the Draize scale. Two rabbits showed a very slight erythema (grade 1) 24 and 48 hours after exposure with full reversibility after 72 hours. No systemic intolerance reactions were observed.
The test item was instilled into the conjunctival sac of the right eye of 3 male rabbits in a study according to OECD TG 405. Eye irritation was assessed using the Draize scale.
The cornea, iris and conjunctivae were not affected by instillation of the test compound. Only a transparent film, consisted probably of test compound, could be observed on the cornea up to 24 hours after exposure. No systemic intolerance reactions were reported.
In a skin irritation/corrosion study according to OECD TG 404 the substance showed an erythema grade 1 in 2/3 rabbits at 24 and 48 hours after exposure. The effect was fully resolved within 72 hours.
Cornea, iris and conjunctivae (redness and chemosis) were not affected after instillation of the test substance in a study according to OECD TG 405 in rabbits.
The substance indicated a low upper respiratory tract irritation potential in an acute aerosol inhalation study (cp. chapter Acute toxicity: inhalation).
No classification is required for skin or eye irritation/corrosion according to Regulation (EC) No 1272/2008, Annex I.
No classification is required for respiratory tract irritation according to Regulation (EC) No 1272/2008, Annex I, because the low vapour pressure of the substance prevents inhalative exposure, and the result of the available acute inhalation study with exposure to a highly respirable aerosol at the targeted limit concentration of 5000 mg/m³ (gravimetrical concentration 4923 mg/m³) did only lead to a mild upper respiratory tract irritation potential.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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