CDX-403

Guidance on Safe Use

First-aid measures

- General advice:

immidiate medical attantion needed

- Following inhalation:

Immediately move exposed subject to fresh air. If not breathing, give artificial respiration. If breathing is labored, administer oxygen. Immediately notify medical personnel and supervisor.

- Following skin contact:

Wash exposed area with soap and water and remove contaminated clothing/shoes. If irritation occurs or persists, notify medical personnel and supervisor.

- Following eye contact:

If easy to do, remove contact lenses, if worn. Immediately flush eyes with copious quantities of water for at least 15 minutes. If irritation occurs or persists, notify medical personnel and supervisor.

- Following ingestion:

If swallowed, call a physician immediately. Do not induce vomiting unless directed by medical personnel. Do not give anything to drink unless directed by medical personnel. Never give anything by mouth to an unconscious person. Notify medical personnel and supervisor.

- Most important symptoms and effects: May cause allergy or asthma symptoms or breathing difficulties if inhaled.

Mixture contains an enzyme/protein that may cause allergic reactions. Medical conditions aggravated by exposure: None known or reported. Treat symptomatically and supportively.

Fire-fighting measures

- Suitable extinguishing media:

Use water spray (fog), foam, dry powder, or carbon dioxide, as appropriate for surrounding fire and materials.

- Flammabillity: No explosivity or flammability data identified. High concentrations of finely divided airborne organic particles can potentially explode if ignited.

- Special hazards arising from the substance or mixture:

No information identified. May emit toxic gases of carbon monoxide and carbon dioxide

- Advice for fire fighter: In case of fire in the surroundings, use the appropriate extinguishing agent. Wear full protective clothing and an approved, positive pressure, self-contained breathing apparatus. Decontaminate all equipment after use.

Accidental release measures

- Personal precautions:

If product is released or spilled, take proper precautions to minimize exposure by using appropriate personal protective equipment. Area should be adequately ventilated.

- Environmental precautions:

Do not empty into drains. Avoid release to the environment.

- Methods and material for containment and cleaning up: DO NOT RAISE DUST. Surround spill or powder with absorbents and place a damp cloth or towel over the area to minimize entry of powder into the air. Add excess liquid to allow the material to enter into solution. Capture remaining liquid onto spill absorbents. Place spill materials into a leak-proof container for disposal in accordance with applicable waste disposal regulations. Decontaminate the area twice with an appropriate solvent.

Handling and storage

- Precautions for safe handling:

Follow recommendations for handling pharmaceutical agents (i.e., use of engineering controls and/or other personal protective equipment if needed). Avoid contact with eyes, skin and other mucous membranes. Wash thoroughly after handling. Avoid breathing dust.

- Conditions for safe storage, including any incompatibilities: Store at -20°C in tightly sealed containers. Protect against physical damage

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

not assigned

Shipping information

Proper shipping name and description:

non assigned

Chemical name:

Halohydrin dehalogenase enzyme

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

Shipping

Remarks

Shipping

Remarks

SpecialProvisions

Exposure controls / personal protection

1. Organisational protection measures:

Selection and use of containment devices and personal protective equipment should be based on a risk assessment of exposure potential. Use local exhaust and/or enclosure at dust-generating points. Emphasis is to be placed on closed material transfer systems and process containment, with limited open handling of powders. High-energy operations such as milling, particle sizing, spraying or fluidizing should be done within an approved emission control or containment system.

2. Hand protection:

Selection and use of containment devices and personal protective equipment should be based on a risk assessment of exposure potential. Use local exhaust and/or enclosure at dust-generating points. Emphasis is to be placed on closed material transfer systems and process containment, with limited open handling of powders. High-energy operations such as milling, particle sizing, spraying or fluidizing should be done within an approved emission control or containment system.

3. Skin protection:

Wear appropriate gloves, lab coat, or other protective overgarment if skin contact is likely. Base the choice of skin protection on the job activity, potential for skin contact and solvents and reagents in use.

4. Eye protection:

Wear safety glasses with side shields, chemical splash goggles, or full face shield, if necessary. Base the choice of protection on the job activity and potential for contact with eyes or face. An emergency eye wash station should be available.

5. Respiratory protection:

Choice of respiratory protection should be appropriate to the task and the level of existing engineering controls. For routine powder handling tasks, an approved and properly fitted air-purifying respirator with HEPA filters should provide ancillary protection based on the known or foreseeable limitations of existing engineering controls. Use a powered air-purifying respirator equipped with HEPA filters or combination filters or a positive-pressure air-supplied respirator if there is any potential for an uncontrolled release, when exposure levels are not known or in any other circumstances where a lower level of respiratory protection may not provide adequate protection.

6. Environmental exposure controls:

Avoid release to the environment and operate within closed systems wherever practicable. Liquid emissions should be directed to appropriate pollution control devices. In case of spill, do not release to drains. Implement appropriate and effective emergency response procedures to prevent release or spread of contamination and to prevent inadvertent contact by personnel.

7. other protective measures:

Wash hands in the event of contact with this product/mixture, especially before eating, drinking or smoking. Protective equipment is not to be worn outside the work area (e.g., in common areas or out-of-doors). Decontaminate all protective equipment following use.

Stability and reactivity

1. Reactivity

:No information identified.

2. Chemical stability

: Stable when stored and handled as recommended.

3. Possibility of hazardous reactions

: Thermal decomposition may yield the following: monomer vapors.

4. Conditions to avoid:

No information identified.

5. Incompatible materials:

No information identified.

6. Hazardous decomposition products: No information identified.

Disposal considerations

Waste treatment methods:

Used product should be disposed of according to local, state, and federal regulations. Do not send down the drain or flush down the toilet. All wastes containing the material should be properly labeled. Dispose of wastes in accordance to prescribed federal, state, and local guidelines, e.g., appropriately permitted chemical waste incinerator. Rinse waters resulting from spill cleanups should be discharged in an environmentally safe manner, e.g., appropriately permitted municipal or on-site wastewater treatment facility.