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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Partition coefficient

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Administrative data

Endpoint:
partition coefficient
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2020
Report date:
2020

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
not specified
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Halohydrin dehalogenase
Cas Number:
132421-41-1
IUPAC Name:
Halohydrin dehalogenase
Test material form:
solid
Details on test material:
Lot number PF 791

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
<= 0
Temp.:
23 °C
Remarks on result:
other: Since thesubstance does not dissolve in octanol, the partitioncoefficient is not reportable
Remarks:
. No data availble on the pH
Details on results:
There was no solubility in the octanol phase at 23 °C and therefore no reportable value is available.

Applicant's summary and conclusion

Conclusions:
The partitioning coefficient was set to be ≤ 0, due to the fact that no substance was disolved in octanol.
Executive summary:

A study on CDX-403  was performed to determine the partition coefficient of the test substance, halohydrin dehalogenase enzyme, according to OECD Method 107.  There was no solubility in the octanol phase at 23 °C and therefore no value is available. The partitioning coefficient was set to ≤ 0.