Registration Dossier
Registration Dossier
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EC number: 214-093-2 | CAS number: 1079-66-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1973
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Remarks:
- Study available in EPA (TSCA8e submission file). The study was not performed under GLP. No guideline followed.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test material was generated into a 32 liter positive pressure inhalation chamber by means of a Midget Impigner. The exposure was 1-hour and the test animals were observed for 14-days after exposure.
- GLP compliance:
- no
- Test type:
- fixed concentration procedure
- Limit test:
- no
Test material
- Reference substance name:
- Chlorodiphenylphosphine
- EC Number:
- 214-093-2
- EC Name:
- Chlorodiphenylphosphine
- Cas Number:
- 1079-66-9
- Molecular formula:
- C12H10ClP
- IUPAC Name:
- diphenylphosphinous chloride
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Duration of exposure:
- 1 h
- Concentrations:
- 0.95 and 2.32 mg/l
- No. of animals per sex per dose:
- 10
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2.32 mg/L air
- Exp. duration:
- 45 min
- Remarks on result:
- other: The concentration 2.32 mg/l had to be terminated at 45 minutes due to crystallization of the test material.
- Clinical signs:
- other: No apparent signs of toxicity were observed at the 0.95 mg/L test concentration. The 2.32 mg/L test concenration produced gasping, depressions, and mild eye irritation, subsiding upon removal from chamber.
- Gross pathology:
- All animals appeared normal when necropsied 14 days after exposure.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The LC50 was determined to be higher than 2.32 mg/L after 45 minutes of exposure.
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