Registration Dossier
Registration Dossier
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EC number: 214-093-2 | CAS number: 1079-66-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study available in EPA (TSCA8e submission file). The study was not performed under GLP. The data are well documented and the data acceptable
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Guideline:
- other: Code of Federal Regulations, Part 191.12, Chap. 1, Title 21
- Principles of method if other than guideline:
- The test material was administered neat in single dose by means of a stomach tube. the animals were fasted for 24 hours prior to treatment.
The animals were observed for 14 days after treatment for mortalities and signs of toxicity. All mortalities and the 14-day survivors of the highest test levels were autopsied for gross pathological observation. - GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Chlorodiphenylphosphine
- EC Number:
- 214-093-2
- EC Name:
- Chlorodiphenylphosphine
- Cas Number:
- 1079-66-9
- Molecular formula:
- C12H10ClP
- IUPAC Name:
- diphenylphosphinous chloride
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 215, 464, 1000, 2150 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 316 mg/kg bw
- Mortality:
- 215 mg/kg: 0/5
464, 1000, 2150 mg/kg: 5/5 - Clinical signs:
- other: All test levels higher than 215 mg/kg produced severe depression.
- Gross pathology:
- The fatalities exhibited extensive hemorrhaging of the upper gastrointestinal tract. The survivors appeared normal when necropsied 14-days after treatment.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The oral LD50 was calculated to be 316 mg/kg bw.
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