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EC number: 252-512-0 | CAS number: 35325-02-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- genetic toxicity in vivo, other
- Type of information:
- (Q)SAR
- Remarks:
- QSAR Toolbox gives a Qualitative prediction of in vivo Chromosome aberration .
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Data source
Reference
- Reference Type:
- other: Software
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals, May 2008
- Deviations:
- no
- Principles of method if other than guideline:
- The data are taken from the: ECHA CHEM database on Genetic Toxicity.
- GLP compliance:
- no
- Type of assay:
- other: QSAR/ read across modeled data
Test material
- Reference substance name:
- N-(2-hydroxypropyl)benzenesulphonamide
- EC Number:
- 252-512-0
- EC Name:
- N-(2-hydroxypropyl)benzenesulphonamide
- Cas Number:
- 35325-02-1
- Molecular formula:
- C9H13NO3S
- IUPAC Name:
- N-(2-hydroxypropyl)benzenesulphonamide
- Test material form:
- liquid: viscous
Constituent 1
Test animals
- Details on species / strain selection:
- Experimantal data were retrieved from differnt test animas ( Chinese hamster, mouse, rat)
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
Test results
- Key result
- Genotoxicity:
- negative
- Remarks on result:
- other: in vivo chromosome aberration based on QSARtoolbox
- Additional information on results:
- -prediction approach: read across among category members Experimental values for the target substance (if any) were not used in prediction calculations
- calculation approach: Taking highest mode value from the 5 nearest neighbours
- descriptor: log Kow N-n-(hydroxylpropyl) benzenesulphoneamide : 0.280
-Prediction confidence: 100.0%; 20 of 20 neighbours' data points have experimental value equal to prediction "Negative"
- predicted value "in vivo chromosome aberration= negative" corresponds to "negative " on the scale of "negative, positive and there were no statistical significant changes”.
- Profiling results for the target substance: DNA binding by OASISv 1.2: No alert found, DNA binding by OECD: No alertfound, Estrogen Receptor Binding: No binder, without OH or NH2 group, OECD HPV Chemical Categories: Not categorized, Protein binding by OASIS v1.2: No alert found, Protein binding by OECD; No alert found, Protein Binding Potency: Not possible to classify according to these rules, Superfragments: No superfragment, Toxic hazard classification by Cramer (original) High( classIII), Toxic hazard classification by Cramer (with extension)High (class III), US-EPA New Chemical Categories: Not categorized
Any other information on results incl. tables
Endpoints | Descriptor | |
in vivo chromosome aberration | log Kow | |
Target chemical | 0.280 | |
chemical No 1 cas 79 -10 -7 | negative | 0.440 |
chemical No 2 cas 7237 -83 -4 | negative | 0.120 |
chemical No 3 cas 872 -50 -4 | negative | -0.110 |
chemical No 4 cas 7195-44 -0 | negative | 0.740 |
chemical No 5 cas 110 -71 -4 | negative | -0.210 |
chemical No 6 cas 122 -99 -6 | negative | 1.10 |
chemical No 7 cas 15214 -89 -8 | negative | -0.610 |
chemical No 8 cas 57 -55 -6 | negative | -0.780 |
chemical No 9 cas 109 -86 -4 | negative | -0.910 |
chemical No 10 cas 55 -63 -0 | negative | 1.51 |
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
The predicted value for N-n-(2-hydroxypropyl)benzenesulphonamide for the in vivo chromosome aberration test was negative, using the OECD QSARtoolbox . - Executive summary:
For the determination of the in vivo chromosome aberration potential of N-n-(2 -hydroxypropyl)benzenesulphonamide the OECD QSAR toolbox was used. For the prediction read-across among category members was applied and 5 nearest neighbours (compounds with CAS n° 79 -10 -7, 7237 -83 -4, 872 -50 -4, 7195 -44 -0,110 -71 -4) were taken. Log Kow was taken into account as descriptor. For the target compound, log Kow is 0.280 and the 5 neighbours were within the log Kow range of -0.211 -0.741.
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