Registration Dossier
Registration Dossier
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EC number: 252-512-0 | CAS number: 35325-02-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- N-(2-hydroxypropyl)benzenesulphonamide
- EC Number:
- 252-512-0
- EC Name:
- N-(2-hydroxypropyl)benzenesulphonamide
- Cas Number:
- 35325-02-1
- Molecular formula:
- C9H13NO3S
- IUPAC Name:
- N-(2-hydroxypropyl)benzenesulphonamide
- Test material form:
- liquid: viscous
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- dose vomume was maintained at 10ml/kg b.w.
- Doses:
- 2000mg/kg b.w.
- Control animals:
- no
- Details on study design:
- In a limit test, one overnight fasted female rat was administered orally 2000 mg/kg b.w. of the test substa,nce mixed with corn oil. As the animal survived four additional animals were dosed sequentially with the same dose of 2000mg/kg b.w .Each time a signal aniaml was dosed.
Following dosing, rats were observed for14 days for mortality and clinical signs of toxicity. body weigts of animal were noted at t the start of the experiment and weekly. A gross necropsy wa perfprmed an all animals on day 14
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortality was observed
- Clinical signs:
- other: No cliniclas signs of toxicity was observed
- Gross pathology:
- no macroscopic lesions
- Other findings:
- no
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral LD50 of N-n(2-hydroxypropyl)benzensulphonamide was determined to be >2000mg/kg b.w fot wistar rat under the experimental conditions tested
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