N-(2-hydroxypropyl)benzenesulphonamide

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

(Q)SAR

Adequacy of study:

key study

Study period:

2013

Reliability:

2 (reliable with restrictions)

Justification for type of information:

ECOSAR is an accepted and well validated QSAR prediction for short term toxicity to aquatic invertebrates

Qualifier:

according to guideline

Guideline:

other: REACH quidance on QSARS R6 May 2008

Principles of method if other than guideline:

ECOSAR is a general model for aquatic toxicity of organic substances. In ECOSAR, substances for which the ecotoxicity is estimated are entitled to chemical classes according to their chemical structure. For each class the ecotoxicity values for acute and chronic endpoints are estimated.

GLP compliance:

no

Test type:

other: QSAR modeled data

Water media type:

freshwater

Total exposure duration:

48 h

Key result

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

ca. 3 002 mg/L

Details on results:

Validity: see QMRF and QPRF

Validity criteria fulfilled:

yes

Conclusions:

The estimated 48-hr LC50 value for Daphnid for N-(2-hydroxypropyl)benzensuphone amide is 3002 mg/l (ECOSAR v1.10).

Executive summary:

The acute aquatic toxicity was estimated using the ECOSAR model v1.10 included in the EpiSuite models of US-EPA. In ECOSAR, substances for which the ecotoxicity is estimated are entitled to chemical classes according to their chemical structure. For each class the ecotox values for acute and chronic endpoints are estimated. N-(hydroxypropyl)benzene sulfonamide is classified under the class of Neutral organics. The estimated 48-hr LC50 value for Daphnids is 3002 mg/l.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

3 002 mg/L