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Environmental fate & pathways

Hydrolysis

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017
Reliability:
2 (reliable with restrictions)
Justification for type of information:
OECD test protocol
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
GLP compliance:
no
Preliminary study:
The preliminary hydrolysis test for N-(2-hydroxypropyl) benzene sulfonamide was conducted at 50 ± 0.5°C in the dark at each of pH 4, 7 and 9 for 5 days. The results of the preliminary study are summarized below


Analysis of pH 4 buffer solution at Day 5 showed >90% of the recovered test item compared to the 0 Hour analysis.

Analysis of pH 7 buffer solution at Day 5 showed >90% of the recovered test item compared to the 0 Hour analysis.

Analysis of pH 9 buffer solution showed >90% of the recovered test item compared to the 0 Hour analysis.

N-(2-hydroxypropyl) benzene sulfonamide was hydrolytically stable at pH 4, pH 7 and pH 9 based on the preliminary result. So definitive study was not conducted.
Transformation products:
no
Remarks:
no transformation products exist as the substance was stable under the experimental conditions.
% Recovery:
> 90
pH:
4
Temp.:
50 °C
Duration:
5 d
% Recovery:
> 90
pH:
7
Temp.:
50 °C
Duration:
5 d
% Recovery:
90
pH:
9
Temp.:
50 °C
Duration:
5 d
Key result
Temp.:
50 °C
Hydrolysis rate constant:
ca. 0 min-1
Conclusions:
This study demonstrated that N-(2-hydroxypropyl) benzene sulfonamide was hydrolytically stable at pH 4, 7 and 9. Based on the results of this study, hydrolysis will not be a route of degradation of N-(2-hydroxypropyl) benzene sulfonamide in the environment
Executive summary:

The preliminary hydrolysis test for N-(2-hydroxypropyl) benzene sulfonamide was conducted at 50 ± 0.5°C in the dark at each of pH 4, 7 and 9 for 5 days. The results of the preliminary study are summarized below. Analysis of pH 4 buffer solution at Day 5 showed >90% of the recovered test item compared to the 0 Hour analysis. Analysis of pH 7 buffer solution at Day 5 showed >90% of the recovered test item compared to the 0 Hour analysis. Analysis of pH 9 buffer solution showed >90% of the recovered test item compared to the 0 Hour analysis. N-(2-hydroxypropyl) benzene sulfonamide was hydrolytically stable at pH 4, pH 7 and pH 9 based on the preliminary result. So definitive study was not conducted.

Description of key information

The preliminary hydrolysis test for N-(2-hydroxypropyl) benzene sulfonamide was conducted at 50 ± 0.5°C in the dark at each of pH 4, 7 and 9 for 5 days. The results of the preliminary study are summarized below. Analysis of pH 4 buffer solution at Day 5 showed >90% of the recovered test item compared to the 0 Hour analysis. Analysis of pH 7 buffer solution at Day 5 showed >90% of the recovered test item compared to the 0 Hour analysis. Analysis of pH 9 buffer solution showed >90% of the recovered test item compared to the 0 Hour analysis. N-(2-hydroxypropyl) benzene sulfonamide was hydrolytically stable at pH 4, pH 7 and pH 9 based on the preliminary result. So definitive study was not conducted.

Key value for chemical safety assessment

at the temperature of:
50 °C

Additional information