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EC number: 401-300-8
CAS number: 86168-95-8
In a subacute study with rats (Ciba-Geigy, 1986) the test substance did not cause any adverse effects up to the highest dose tested (1000 mg/kg), therefore, the NOAEL was set at 1000 mg/kg bw.
In a GLP-compliant subacute rat study (OECD 407), a total of 40 RAIf
rats (5 males and 5 females per dose group) were dosed by gavage with 0,
40, 200 and 1000 mg/kg body weight daily for 28 days (Ciba-Geigy, 1985).
No relevant clinical signs and no mortalities related to administration
of the test substance were observed during the treatment or recovery
periods. No changes to body weight gain food consumption and water
consumption were noted. In hematology, a minor increase in the
percentage of segmented neutrophils was found in males and females of
the high dosage group (1000 mg/kg bw), but the difference to controls
was not reaching a level of statistical significance. Blood chemistry
analysis revealed a minor (statistically not significant) increase in
aspartate aminotransferase activity in the male group 4, treated with
1000 mg/kg bw, but no changes attributable to the treatment with the
test article were found. Besides some incidental findings in organ
weight parameters and microscopy investigations, no effects of
toxicological significance attributed to treatment were observed.
Therefore, the NOAEL was set at 1000 mg/kg/day under the conditions of
Dangerous Substance Directive (67/548/EEC)
The available experimental test data is reliable and suitable for the
purpose of classification under Directive 67/548/EEC. Based on the
present data, classification for repeated dose oral toxicity is not
warranted under Directive 67/548/EEC.
Classification, Labeling, and Packaging Regulation (EC) No.
The available experimental test data are reliable and suitable for the
purpose of classification under Regulation (EC) No.1272/2008. Based on
the present data, classification for repeated dose oral toxicity is not
warranted under Regulation (EC) No.1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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