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EC number: 401-300-8
CAS number: 86168-95-8
- Acute oral toxicity (OECD guideline 401): LD50 > 5000 mg/kg bw (CIBA-GEIGY Ltd., 850040, 1985)- Acute dermal toxicity (OECD guideline 402): LD50 > 2000 mg/kg bw (CIBA-GEIGY Ltd., 850043, 1985)
Acute oral toxicity
The acute oral toxicity of the test substance was assessed in rats
following OECD guideline 401 (CIBA-GEIGY Ltd., 850040, 1985) and under
GLP-like quality controlled conditions. In the limit test, a single dose
of 5000 mg/kg body weight in distilled water containing 0.5%
carboxymethylcellulose and 0.1% polysorbate 80 was applied once by
gavage to five male and five female rats following an observation period
of 14 days. No mortality occurred within the timeframe of the study.
Dyspnea, exophthalmos, ruffled fur, and curved body position were seen,
being common symptoms in acute tests. The animals recovered within 13
days. Body weight gain was normal and necropsy did not reveal any
abnormalities. Overall, under the chosen test conditions, the test
substance was not toxic after single oral administration: Oral LD50 >
5000 mg/kg body weight
Acute dermal toxicity
As a second exposure route acute dermal toxicity was investigated
(CIBA-GEIGY Ltd., 850043, 1985). In the study according to OECD
guideline 402 and under GLP-like quality assurance, the Standard Acute
Method using a single dose of 2000 mg/kg body weight (vehicle: distilled
water containing 0.5%carboxymethylcellulose and 0.1% polysorbate 80) in
a limit test was performed using five male and five female rats. The
rats were treated semi-occlusively for 24 hours and then observed for 14
consecutive days. No mortality occurred within the timeframe of the
study. Clinical signs were limited to dyspnea, ruffled fur, and abnormal
body positions, being common symptoms in acute tests. Additionally,
diarrhea was observed on day 1 after application. All animals recovered
within 13 days. Body weight gain was normal and no deviations from
normal morphology were found at autopsy. Overall, under the chosen test
conditions, the test substance does not have toxic properties in case of
single dermal exposure: Dermal LD50 > 2000 mg/kg body weight.
Acute inhalation toxicity
No data available.
Dangerous Substance Directive (67/548/EEC)
The available experimental test data is reliable and suitable for the
purpose of classification under Directive 67/548/EEC. Based on the data,
classification for acute toxicity is not warranted under Directive
Classification, Labeling, and Packaging Regulation (EC) No.
The available experimental test data are reliable and suitable for the
purpose of classification under Regulation (EC) No.1272/2008. Based on
the data, classification for acute toxicity is not warranted under
Regulation (EC) No.1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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