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EC number: 401-300-8
CAS number: 86168-95-8
The test article was investigated for its clastogenic potential in an in
vivo nucleus anomaly test performed in Chinese hamsters similar to OECD
TG 474 (Ciba-Geigy, 850047, 1985). The test substance was administered
by gavage in daily doses of 1250, 2500 or 5000 mg/kg on each of two
consecutive days. The animals were sacrificed 24 h after the second
application and smears from the bone marrow were made. Treatment with
the test article with the various doses did not result in significant
increases in nucleus anomalies when compared to the control. By
contrast, a "positive control" experiment with cyclophosphamide (128
mg/kg) yielded 8.08% cells with anomalies of nuclei. This is
significantly different from the controls (0.08%) treated with the
vehicle (0.5% CMC) alone. It is concluded that under the conditions of
this experiment, no evidence of mutagenic effects was obtained in
Chinese hamsters treated with the test substance.
Dangerous Substance Directive (67/548/EEC)
The available experimental test data is reliable and suitable for the
purpose of classification under Directive 67/548/EEC. Based on the
present data, classification for genotoxicity is not warranted under
Classification, Labeling, and Packaging Regulation (EC) No.
The available experimental test data are reliable and suitable for the
purpose of classification under Regulation (EC) No.1272/2008. Based on
the present data, classification for genotoxicity is not warranted under
Regulation (EC) No.1272/2008.
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