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EC number: 401-300-8 | CAS number: 86168-95-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation (OECD 404 & GLP): not irritating (rabbit, in vivo) (CIBA-GEIGY Ltd., 805042, 1985)
Eye irritation (OECD 405 & GLP): not irritating (rabbit, in vivo) (CIBA-GEIGY Ltd., 805041, 1985)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation
The test article's potential to cause dermal irritation was assessed in a GLP-compliant study following OECD guideline 404 (CIBA-GEIGY Ltd., 850042, 1985). An amount of 0.5 g of the test substance was applied topically to the intact skin of 3 male rabbits for 4 hours under occlusive dressing. In two animals slight erythema reactions were observed one hour after removing of the dressing, reversible within 24 hours. All scores at the 24, 48 and 72 hour time points were zero. The third animal showed mild erythema and edema reactions, reversible after 72 and 48 hours, respectively. The mean scores over 24, 48 and 72 hour readings in this animal were 0.66 for erythema and 0.33 for edema. Overall, only minimal skin reactions could be observed and in conclusion, under the test conditions chosen, the test substance is not considered to be irritating to the skin.
Eye irritation
To assess the acute eye irritation potential of the test substance in vivo, a GLP-compliant study with three New Zealand white rabbits was performed according to OECD guideline 405 (CIBA-GEIGY Ltd., 850041, 1985). An amount of 0.1 g of the test substance was applied into the conjunctival sac of the right eye of each animal and the ocular reactions were evaluated 1, 24, 48, and 72 hours after instillation. All animals displayed mild reactions to the conjunctivae (reddening) and minimal chemosis (after 1 hour of instillation only). The mean conjunctiva scores (24 - 72 hours) for each animal were 0.33, 0.33 and 1, all reactions were reversed to normal after 72 hours the latest. Since the observed reactions were minimal and below the regulatory threshold of significance, the test article is considered to be not irritating to the rabbit eye.
Respiratory Irritation
No data
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available experimental test data is reliable and suitable for the purpose of classification under Directive 67/548/EEC.
Based on the data, the test substance is not classified as skin or eye irritant.
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for the purpose of classification under Regulation (EC) No.1272/2008.
Based on the data, the test substance is not classified as skin or eye irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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