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EC number: 401-300-8
CAS number: 86168-95-8
The test substance was investigated for its sensitizing potential in a
GLP-compliant Maximization test according to OECD guideline 406
(CIBA-GEIGY Ltd., 850044, 1993). Pirbright White guinea pigs received
intradermal induction treatments with 1% in sesame oil and one
epicutaneous induction treatment with 30% in vaseline. For intradermal
induction, three pairs of injections (adjuvant/saline; test item in
vehicle; test item in vehicle plus adjuvant/saline) were given.
Epidermal challenge was performed by occlusive application for 24 h two
weeks later (10% in vaseline). No skin reactions were observed either
for control or test group animals and therefore no animal was sensitized
by the test article under the experimental conditions employed. The
sensitivity of the strain is controlled every six month with p -
phenylenediamine. In conclusion, the test substance is not considered to
be a skin sensitizer in albino guinea pigs and does not require
Dangerous Substance Directive (67/548/EEC)
The available experimental test data is reliable and suitable for the
purpose of classification under Directive 67/548/EEC. Based on the
present data, classification for sensitization is not warranted under
Classification, Labeling, and Packaging Regulation (EC) No.
The available experimental test data are reliable and suitable for the
purpose of classification under Regulation (EC) No.1272/2008. Based on
the present data, classification for sensitization is not warranted
under Regulation (EC) No.1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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