Registration Dossier
Registration Dossier
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EC number: 273-054-8 | CAS number: 68937-17-7
Endpoint summary
Administrative data
Description of key information
No in vitro or in vivo skin and eye irritation data are available for Disilane, chloro Me derivs. However, the available information on the properties of this substance indicate that it is corrosive, therefore in accordance with Column 2 of REACH Annexes VII and VIII, further testing for skin and eye irritation/corrosion is not required.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Disilane, chloro Me derivs. is a multi-constituent substance comprising main constituents with the generic formula:
(Clx)(Me3-x)Si - Si(Me3 -y)(Cly); where X and Y = 1 or 2
and a number of minor constituents which are also chloromethylsilanes or chloromethyldisilanes.
All of these constituents hydrolyse rapidly in contact with moisture (half-life of a few minutes at pH 4, 7 and 9 and 1.5°C; at physiological temperature, hydrolysis will be much faster), generating up to 4 moles of hydrogen chloride (HCl) for each mole of parent constituent. As such, the substance is therefore expected to be corrosive to skin, eyes and the respiratory tract, consistent with in vivo data for other chlorosilanes.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Effects on respiratory irritation: highly irritating
Justification for classification or non-classification
Based on the generation of HCl in contact with water, Disilane, chloro Me derivs. is classified as "Corrosive" and labelled R35 "Corrosive" under the criteria of EU Directive 67/548/EEC and "Skin Corr. 1A" under Regulation 1272/2008.
Consistent with other chlorosilanes, the additional classification of EUH0 71 "Corrosive to respiratory tract" is also proposed.
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