Registration Dossier
Registration Dossier
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EC number: 609-106-7 | CAS number: 35249-89-9
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study results have been reported in a review and it was not possible to evaluate the original study.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- SCREENING-LEVEL HAZARD CHARACTERIZATION - Glycolic Acid (CASRN 79-14-1). Hazard Characterization Document
- Author:
- U.S. Environmental Protection Agency
- Year:
- 2 010
- Bibliographic source:
- U.S. Environmental Protection Agency
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Green Algae (Pseudokirchneriella subcapitata; 3 replicates/concentration) were exposed to glycolic acid at mean measured concentrations of 7.52, 14.5, 30.3, 54.6 and 73.6 mg/L for 72 hours.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Glycollic acid
- EC Number:
- 201-180-5
- EC Name:
- Glycollic acid
- Cas Number:
- 79-14-1
- Molecular formula:
- C2H4O3
- IUPAC Name:
- glycol acid
- Reference substance name:
- 2-hydroxyacetic acid
- IUPAC Name:
- 2-hydroxyacetic acid
- Reference substance name:
- Glycolic Acid
- IUPAC Name:
- Glycolic Acid
- Test material form:
- not specified
Constituent 1
Constituent 2
Constituent 3
Sampling and analysis
- Analytical monitoring:
- not specified
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
Study design
- Test type:
- not specified
- Water media type:
- not specified
- Total exposure duration:
- 216 h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 44 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 21.6 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- biomass
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Pseudokirchneriella subcapitata 72-h EC50 (growth) = 44.0 mg/L
Pseudokirchneriella subcapitata 72-h EC50 (biomass) = 21.6 mg/L - Executive summary:
Green Algae (Pseudokirchneriella subcapitata; 3 replicates/concentration) were exposed to glycolic acid at mean measured concentrations of 7.52, 14.5, 30.3, 54.6 and 73.6 mg/L for 72 hours.
At the end of the 72-hour exposure period, a control replicate and samples from the test concentrations exhibiting a 50% or greater inhibition of cell counts were selected for a recovery test and exposed to nutrient medium for an additional 144 hours.
72-h EC50(growth) = 44.0 mg/L
72-h EC50(biomass) = 21.6 mg/L
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