Registration Dossier
Registration Dossier
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EC number: 609-106-7 | CAS number: 35249-89-9
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study results have been reported in a review and it was not possible to evaluate the original study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Final report on the safety assessment of glycolic acid, ammonium, calcium, potassium, and sodium glycolates, methyl, ethyl, propyl, and butyl glycolates, and lactic acid, ammonium, calcium, potassium, sodium and tea-lactates, methyl, ethyl, isopropyl, and
- Author:
- Cosmetic Ingredient Review
- Year:
- 1 998
- Bibliographic source:
- Microbiological Associates, Inc., 1994, as cited by International Journal of Toxicology, 17(Suppl. 1):1-3.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Glycollic acid
- EC Number:
- 201-180-5
- EC Name:
- Glycollic acid
- Cas Number:
- 79-14-1
- Molecular formula:
- C2H4O3
- IUPAC Name:
- glycol acid
- Reference substance name:
- 2-hydroxyacetic acid
- IUPAC Name:
- 2-hydroxyacetic acid
- Reference substance name:
- Glycolic Acid
- IUPAC Name:
- Glycolic Acid
- Test material form:
- not specified
- Details on test material:
- Glycolic Acid, 20% active ingredient
Constituent 1
Constituent 2
Constituent 3
Method
Species / strain
- Species / strain / cell type:
- other: TA98, TA100, TA1535, TA1537, and TA1538
- Metabolic activation:
- with and without
Results and discussion
Any other information on results incl. tables
Glycolic Acid was not mutagenic in this Ames test.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Glycolic Acid was not mutagenic in this Ames test. - Executive summary:
An Ames test was performed to determine the mutagenic potential of Glycolic Acid, 20% active ingredient, using Salmonella typhimurium strains TA98, TA100, TA1535, TA1537, and TA1538 with and without metabolic activation. Glycolic Acid was not mutagenic in this Ames test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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