Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 609-106-7 | CAS number: 35249-89-9
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study results have been reported in a review and it was not possible to evaluate the original study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Final report on the safety assessment of glycolic acid, ammonium, calcium, potassium, and sodium glycolates, methyl, ethyl, propyl, and butyl glycolates, and lactic acid, ammonium, calcium, potassium, sodium and tea-lactates, methyl, ethyl, isopropyl, and
- Author:
- Cosmetic Ingredient Review
- Year:
- 1 998
- Bibliographic source:
- ESLUR, 1994, as cited by International Journal of Toxicology, 17(Suppl. 1):1-3.
Materials and methods
- Principles of method if other than guideline:
- Modified Draize test in which the intradermal injection challenge was 3% and the topical application challenge was 60%.
- GLP compliance:
- not specified
- Type of study:
- Draize test
Test material
- Reference substance name:
- Glycollic acid
- EC Number:
- 201-180-5
- EC Name:
- Glycollic acid
- Cas Number:
- 79-14-1
- Molecular formula:
- C2H4O3
- IUPAC Name:
- glycol acid
- Reference substance name:
- 2-hydroxyacetic acid
- IUPAC Name:
- 2-hydroxyacetic acid
- Reference substance name:
- Glycolic Acid
- IUPAC Name:
- Glycolic Acid
- Test material form:
- not specified
Constituent 1
Constituent 2
Constituent 3
In vivo test system
Test animals
- Species:
- other: not specified
Study design: in vivo (non-LLNA)
- No. of animals per dose:
- not specified
Results and discussion
Any other information on results incl. tables
Glycolic Acid was not a sensitizer.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- In a modified Draize test (species and number of animals not stated) in which the intradermal injection challenge was 3% and the topical application challenge was 60%, Glycolic Acid was not a sensitizer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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