Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP compliance and OECD method

Data source

Reference
Reference Type:
other: ECHA inquiry result
Title:
Unnamed
Year:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD402
GLP compliance:
yes
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol)
EC Number:
403-800-1
EC Name:
2,2'-methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol)
Cas Number:
103597-45-1
Molecular formula:
C41H50N6O2
IUPAC Name:
2-(2H-1,2,3-benzotriazol-2-yl)-6-{[3-(2H-1,2,3-benzotriazol-2-yl)-2-hydroxy-5-(2,4,4-trimethylpentan-2-yl)phenyl]methyl}-4-(2,4,4-trimethylpentan-2-yl)phenol

Test animals

Species:
other: rat, Tif;RAIF(SPF)

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
other: 0.5(w/v)carboxymethylcellulose in 0.1%(w/v) acqueous polysorbate
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male:2000 mg/kg bw;Number of animals:5; Number of deaths:0
Female:2000 mg/kg bw;Number of animals:5; Number of deaths:0
Clinical signs:
other: Signs of toxicity related to dose levels; Piloerection and hunched posture were observed during the study, as is normal with acute studies. All animals revovered within three days.
Gross pathology:
Effects on organs:
No deviation from normal morphology was observed at autopsy

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU