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EC number: 403-800-1
CAS number: 103597-45-1
EVERSORB 78; LOWILITE 36; LS.BT.620; MIXXIM BB/100; TINUVIN 360
The test substance is a white powder
with a molecular weight of 659 g/mol. The log P o/w value is 4.2 and the
solubility in water is < 0.007 mg/l (20°C). The particle size was
examined to be < 18.31μm = 50 % and
< 5.98 μm = 10% .
In an acute oral toxicity study, TIF:
RAIf (SPF) rats were administered doses of up to 2000 mg/kg body weight
per gavage (CIBA-Geigy study, 1992). No mortalities occurred and the
LD50 oral was set to be > 2000
mg/kg body weight. However, according to the physico-chemical properties
(molecular weight, log P o/w) the test substance is expected to be
absorbed through the gastrointestinal tract (ECHA R7c). . Based on the
lipophilic properties of the test substance, the liver appears to be the
main site of metabolism. The metabolites are assumed to be excreted
predominantly via the renal pathway.
The dermal uptake of the test substance
is unlikely due to its physico-chemical properties. The penetration rate
is assumed to be extremely low and the extent is extremely limited
through rat and human split thickness skin membranes. Furthermore, the
test substance did not exhibit any acute dermal toxicity, skin
irritative / corrosive , eye irritative or skin sensitisation properties
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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