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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP compliance and OECD method

Data source

Reference
Reference Type:
other: ECHA inquiry result
Title:
Unnamed
Year:
2013

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: OECD 401
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
other: rat, Tif:RAIF(SPF)

Administration / exposure

Vehicle:
other: 0.5%(w/v) carboxy methylcellulose in 0.1%w/v acqueous polysorbate

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male:2000 mg/kg bw; Number of animals:5; Number of deaths:0
Femaile: 2000 mg/kg bw; Number of animals:5; Number of deaths:0
Clinical signs:
Signs of toxicity related to dose levels:
Only common symptoms such as piloerection, hunched posture
and dyspnea were observed during the study
Gross pathology:
Effects on organs:
No deviation from normal morphology was observed at autopsy

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU