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EC number: 222-852-4
CAS number: 3634-83-1
The acute toxicity of the test substance XDA to Oryzias latipes was studied according to the OECD 203 Guideline under semi-static conditions and in compliance with GLP principles. The 96h-LC50 was determined to be 87.6 mg XDA/L based on analytically confirmed nominal concentrations. For classification purposes, this result was recalculated to 120.9 mg XDI/L.
fish studies are available: one with XDI and one with the main
transformation product XDA. Based on the rapid transformation of the
parent material XDI to XDA, it was deemed important to also evaluate the
toxicity of the pure transformation product XDA.
toxicity of XDI to Oryzias latipes was tested in a semi-static test
system in accordance with OECD guideline 203 and the principles of Good
Laboratory Practice. Test solutions were prepared by adding XDI to test
medium, and allowing the substance to dissociate completely. The results
were expressed as mean measured concentrations of the transformation
product XDA (instead of nominal concentrations of XDI) and subsequently
recalculated to the parent material XDI. So, the 96h-LC50 values were >
11 mg XDA/L and > 15.2 mg XDI/L.
studies were reviewed and determined to be reliable. Although the XDA
study received a lower Klimisch value due to a pH issue (pH partly out
of the range advised by the test guideline), it was judged that this
issue did not influence the results of the study.
of both studies were of the same magnitude. Based on the fact that the
results of the acute fish study with XDA were bound values and the
results with XDI unbound values (> values), it was decided to use the
bound values of XDA as key value for this endpoint.
for chemical safety assessment: 96h-LC50 for freshwater fish: 87.6 mg
for classification purposes: 96h-LC50 for freshwater fish: 120.9 mg XDI/L
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