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EC number: 222-852-4
CAS number: 3634-83-1
The average of MNIE% in the negative control and positive control groups
were 0.17 and 3.47% respectively. MNIE% in te test substance groups was
0.13% at 250 mg/kg/day, 0.11% at 500 mg/kg/day and 0.10% at 1000
mg/kg/day. Thus, no significant increase was noted at any dose of the
test substance treatment groups when compared with the negative control
group. A significant increase was observed in the positive control group.
IE% in the negative control and positive control groups were 58.0 and
54.4% respectively. IE% at 250 mg/kg/day was 58.7%, at 500 mg/kg/day was
58.3% and at 1000 mg/kg/day was 55.6%. Thus, no significant difference
was noted at any doses of the treatment groups and the positive control
group compared with the negative control group.
In an in vivo micronucleus study performed according to OECD test
guideline 474, XDI was administered orally twice up to 1000 mg/kg bw/day
to rats. The frequency of the micronuclei did not increase by
administering the test substance to rats. The positive control showed a
significant increase compared to the negative control, it was confirmed
that the test was valid. The exposure of substance to bone marrow cells
could not be proved as the IE% did not show significant differences in
substance treated compared to negative control. However, doses were set
based on dead animals found after 4 days of administration in 14-d
repeated dose toxicity study, and toxic symptoms indicative of systemic
exposure were observed in this study. The potential to induce
micronuclei could be evaluated adequately in this study. Therefore, it
was concluded that XDI had no potential to induce the micronuclei under
the present test conditions.
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