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EC number: 222-852-4
CAS number: 3634-83-1
The growth inhibition test of the test substance with green algae was conducted with the test substance XDA according to OECD 201 and in compliance with GLP principles. The ErC50 (0 -72) and the ErC10 (0 -72) were calculated to be 31.5 mg XDA/L and 21.6 mg XDA/L, resp. These values correspond to ErC50 (0 -72) of 43.5 mg XDI/L and ErC10 (0 -72) of 29.8 XDI/L.
toxicity studies to aquatic algae are available: one with XDI and one
with the main transformation product XDA. Based on the rapid
transformation of the parent material XDI to XDA, it was indeed deemed
important to also evaluate the toxicity of the pure transformation
were expressed as mean measured concentrations of the transformation
product XDA (instead of nominal concentrations of XDI) and subsequently
recalculated to the parent material XDI. So, the 72h- ErC50 and
72h-ErC10 were both > 23 mg XDA/L and > 31.7 mg XDI/L.
studies were reviewed and determined to be reliable. Although
the XDA study received a lower Klimisch value due to a pH issue (pH
partly out of the range advised by the test guidelines), it was judged
that this issue did not influence the results of the study.
the fact that the results of the green algae study with XDA were bound
values and the results with XDI unbound values (> values), it was
decided to use the bound values of XDA as key value for this endpoint.
for chemical safety assessment: 72h-EC50
for freshwater algae: 31.5 mg XDA/L; EC10 = 21.6 mg XDA/L
for CLP classification: 72h-EC50
freshwater algae: 43.5 mg XDI/L; EC10 = 29.8 mg XDI/L
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