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EC number: 222-852-4
CAS number: 3634-83-1
- At all treated skin sites well-defined (score 2) to severe erythema
(score 3) was noted at the 7 day observation (average of the 3 animals:
- Well-defined and very slight oedema were noted at 2 treated skin sites
at the 14 day observation (averages of the 3 animals: 1.33 (erythema)
and 0.67 (oedema)).
- The oedema extended ventrally below all treated skin sites at the 1 hr
to 72 hrs observations
- Fissuring was noted at 1 treated skin site at the 7 day observation.
- Adverse reactions prevented accurate evaluation of oedema at all
treated skin sites at the 7 day observation
- Crust formation, glossy skin and/or reduced re-growth of fur were
noted at all treated skin sites at the 14 day observation. Reactions
extended up to 5 cm beyond all treatment sites.
In an in vivo skin irritation study in rabbits, conducted in accordance
with OECD 404 and GLP, 2 male and 1 female rabbits were semi-occlusively
exposed for 4 hours to 0.5 mL of the undiluted substance. Well-defined
erythema and severe oedema were noted at all treated skin sites 1 hr
after patch removal and at the 24, 48 and 72 hour observations with
well-defined to severe erythema at the 7 day observation. Erythema was
not fully reversible within 14 days in all 3 animals and oedema in 2 of
the 3 animals. In accordance with the CLP Regulation the substance is
classified as irritating to the skin (Category 2) as the mean value for
oedema in at least 2 of 3 tested animals from gradings at 24, 48 and 72
hours after patch removal is ≥ 2.3.
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