Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 222-852-4
CAS number: 3634-83-1
- At all treated skin sites well-defined (score 2) to severe erythema
(score 3) was noted at the 7 day observation (average of the 3 animals:
- Well-defined and very slight oedema were noted at 2 treated skin sites
at the 14 day observation (averages of the 3 animals: 1.33 (erythema)
and 0.67 (oedema)).
- The oedema extended ventrally below all treated skin sites at the 1 hr
to 72 hrs observations
- Fissuring was noted at 1 treated skin site at the 7 day observation.
- Adverse reactions prevented accurate evaluation of oedema at all
treated skin sites at the 7 day observation
- Crust formation, glossy skin and/or reduced re-growth of fur were
noted at all treated skin sites at the 14 day observation. Reactions
extended up to 5 cm beyond all treatment sites.
In an in vivo skin irritation study in rabbits, conducted in accordance
with OECD 404 and GLP, 2 male and 1 female rabbits were semi-occlusively
exposed for 4 hours to 0.5 mL of the undiluted substance. Well-defined
erythema and severe oedema were noted at all treated skin sites 1 hr
after patch removal and at the 24, 48 and 72 hour observations with
well-defined to severe erythema at the 7 day observation. Erythema was
not fully reversible within 14 days in all 3 animals and oedema in 2 of
the 3 animals. In accordance with the CLP Regulation the substance is
classified as irritating to the skin (Category 2) as the mean value for
oedema in at least 2 of 3 tested animals from gradings at 24, 48 and 72
hours after patch removal is ≥ 2.3.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Deze website maakt gebruik van cookies om het surfen zo aangenaam mogelijk te maken.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again