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EC number: 211-989-5
CAS number: 732-26-3
Table 1: Individual Skin Reactions
Observation Time (hours)
A study was performed to assess the irritancy potential of the test
material in accordance with the standardised guidelines OECD 404 and EU
Method B.4 under GLP conditions.
A single application of 0.5 g of the test material moistened with 0.5 mL
of distilled water was made to the clipped skin of 3 male New Zealand
White rabbits. The skin was exposed in a semi-occlusive fashion for a
period of 4 hours.
Following the exposure period, any residual test material was removed by
gentle swabbing with cotton wool soaked in diethyl ether. Approximately
one hour following the removal of the patches, and 24, 48 and 72 hours
later, the test sites were examined for evidence of primary irritation
and scored according to the Draize scale.
Very slight erythema was noted at all treated skin sites one hour after
patch removal and at one treated skin site at the 24 and 48-hour
observations. Very slight oedema was noted at one treated skin site one
hour after patch removal.
All treated skin sites appeared normal 72 hours after treatment.
Under the conditions of this study the test material was determined to
be non irritating to the skin.
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