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EC number: 211-989-5
CAS number: 732-26-3
Biodegradation in water: screening tests
Two studies are provided to address this endpoint, one experimental and
one prediction. Both were awarded a reliability score of 2 in accordance
with the criteria set forth by Klimisch et al. (1997). The experimental
result has been selected as the key value.
In the key study the inherent biodegradability of the test material was
investigated in a modified MITI (II) test conducted in accordance with
the standardised guideline OECD 302C.
A mixed population of activated sewage sludge microorganisms was exposed
to the test material for a period of 28 days at a concentration of 30
mg/L. The activated sewage was prepared by sampling 10 different sites
around the UK in accordance with the guideline and the inoculum prepared
for exposure by being fed daily with a 0.1 % synthetic sewage and
maintained on a constant aeration at 25 ± 2 °C. The usage rate was
equivalent to 100 mg dry weight/L.
Oxygen consumption was measured by direct manometer reading. Manometer
volumes were recorded daily.
The test material attained 13 % degradation after 28 days, calculated
from oxygen uptake (% of ThOD).
Under the conditions of this study the test material was determined not
to be inherently biodegradable.
In the supporting study the ready biodegradability of the test material
was estimated using the BIOWIN model v4.10 (EPI Suite v4.11).
BIOWIN, the model within EPISUITE which calculates biodegradation,
estimates the probability of rapid aerobic and anaerobic biodegradation
of an organic compound in the presence of mixed populations of
environmental microorganisms. BIOWIN contains seven separate models:
Biowin1 (linear probability model); Biowin2 (nonlinear probability
model); Biowin3 (expert survey ultimate biodegradation model); Biowin4
(expert survey primary biodegradation model); Biowin5 (MITI linear
model); Biowin6 (MITI nonlinear model); and Biowin7 (anaerobic
Sufficient information on the model training set is available to
evaluate the applicability of the model to this substance. The molecular
weight of the test material is within the training set range.
The test material was predicted to be not readily biodegradable.
Biodegradation in water and sediment: simulation tests and
Biodegradation in soil
In accordance with Section 9.2 of Column 2 of REACH Annex IX, further
biotic degradation testing shall be proposed by the registrant if the
Chemical Safety Assessment indicates the need to investigate further the
degradation of the substance and its degradation products.
Due to the properties of this substance, the environmental releases are
strictly controlled and no emission to the environment takes place. The
results of the chemical safety assessment therefore indicate that there
is no need to further investigate biotic degradation.
It is therefore considered justified to omit the simulation testing on
ultimate degradation in surface water, sediment simulation testing ,
identification of degradation products and the soil simulation testing
studies required in sections 126.96.36.199, 188.8.131.52, 9.2.3 and 184.108.40.206 of
Annex IX, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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