Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2019
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Report Date:
2019

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Version / remarks:
2016
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
Version / remarks:
1996
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Details on test material:
Off-white crystalline powder

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficientopen allclose all
Type:
log Pow
Partition coefficient:
1.3
Temp.:
20.1 °C
pH:
2
Type:
log Pow
Partition coefficient:
1.1
Temp.:
20.1 °C
pH:
7.1
Details on results:
pH 2
The analyzed concentration of the stock solution was 0.607 g/L. Based on this the nominal quantity of the test item in the test samples was 1.21 mg. The recoveries were determined according to this value.
The log Pow values were within the criterion range of ± 0.3 log units. The Pow and log Pow of the test item is given as the mean value of all measurements.
No test item was detected in the pretreated samples from the blank mixture. The pH of the blank samples was pH 2.1 and 2.2.

pH 7
The analyzed concentration of the stock solution was 0.434 g/L. Based on this the nominal quantity of the test item in the test samples was 0.869 mg. The recoveries were determined according to this value.
The log Pow values were within the criterion range of ± 0.3 log units. The Pow and log Pow of the test item is given as the mean value of all measurements.
No test item was detected in the pretreated samples from the blank mixture. The pH of the blank samples was pH 7.1.

Applicant's summary and conclusion

Conclusions:
The shake flask method at pH 2 and pH 7 was applied for the determination of the partition coefficient (Pow) of CH02672.
pH 2: The Pow value of the test item was 2.0 * 10^1. It corresponds with a log Pow value of 1.3.
pH 7: The Pow value of the test item was 1.4 * 10^1. It corresponds with a log Pow value of 1.1.