Registration Dossier

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Test material information:
Composition 1
Specific details on test material used for the study:
- Physical Appearance: Almost colourless to yellow-brown liquid
- Date of Expiry: 01-08-2018
- Storage Condition: Ambient (21 to 29°C)
Key result
Water solubility:
252.21 mg/L
Conc. based on:
test mat.
Incubation duration:
>= 24 - <= 72 h
Temp.:
20 °C
pH:
5.5
Details on results:
- System suitability: System suitability meets the acceptance criterion as the % RSD obtained was 0.73% to 4.70% which is less than 5.0%.
- Specificity: Specificity meets the acceptance criterion for the test substance as the interference obtained for diluent was 4.86% which is < 30% of the standard response at LOQ.
- Limit of Detection (LOD) and Limit of Quantification (LOQ): The LOD was determined at 9.45 mg/L and LOQ was determined at 23.61 mg/L
- Linearity: Linearity meets the acceptance criterion as the correlation coefficient obtained was 0.9992 to 0.9999 which is > 0.99.
- Accuracy (% Recovery) and Precision (% RSD): Recovery meets the acceptance criterion as the % recovery obtained was 102.86% for LOQ and 96.59% for 10 LOQ which is within the range 70% to 110% of the nominal concentration at each fortification level. Precision meets the acceptance criterion as the % RSD obtained was 3.20% for LOQ and 6.00% for 10 LOQ which is < 20%.
- Preliminary Test: Preliminary result indicated that the test item had a solubility of more than 10^-2 g/L in milli-Q water.
- Definitive Test: The solubility of the test substance in Milli-Q water was determined to be 242.37 mg/L for 24 hours, 258.44 mg/L for 48 hours and 255.83 mg/L for 72 hours at 20°C.

Description of key information

The water solubility of the test substance is 252.21 mg/L (OECD 105 and GLP).

Key value for chemical safety assessment

Water solubility:
252.21 mg/L
at the temperature of:
20 °C

Additional information