2-hexylcyclopent-2-enone

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7950 (Vapor Pressure)

GLP compliance:

yes (incl. QA statement)

Type of method:

gas saturation method

Specific details on test material used for the study:

- Physical Appearance: Almost colourless to yellow-brown liquid
- Date of Expiry: 01-08-2018
- Storage Condition: Ambient (21 to 29°C)

Key result

Test no.:

#1

Temp.:

20 °C

Vapour pressure:

0.006 Pa

Test no.:

#2

Temp.:

40 °C

Vapour pressure:

0.007 Pa

Method validation

- System suitability meets the acceptance criterion as the % RSD obtained was 0.87% to 4.06% which is less than 5.0%.

- Specificity meets the acceptance criterion as the interference obtained for diluent was 4.84% and for diluent spiked with trapping agent (Matrix) was 9.01% which is < 30% of the standard response at LOQ.

- Linearity meets the acceptance criterion as the correlation coefficient obtained was 1.00 which is > 0.99.

- Limit of Detection (LOD) and Limit of Quantification (LOQ): The LOD was considered at 1.60 mg/L based on S/N ≈ 3/1. The LOQ was considered at 4.00 mg/L based on S/N ≥ 10/1, where silica blank (Matrix) was used to determine the noise.

- Accuracy (% Recovery) and Precision (% RSD): Recovery meets the acceptance criterion as the % recovery obtained was 99.19% for LOQ and 100.75% for 10 LOQ which is in the range of 70 to 110 % of the nominal concentration at each fortification level. Precision meets the acceptance criterion as the % RSD obtained was1.04% for LOQ and 0.87% for 10 LOQ which is<20.0%.

- Stability meets the acceptance criterion as the % recovery obtained was 98.34% for 0 day which is in the range of 70 to 110% of the nominal concentration. Stability meets the acceptance criterion as the % recovery obtained was 104.78% for 3 days at 40ºC which is in the range of 70 to 110% of the nominal concentration.

Tests:

- Preliminary Test – Gas Saturation Method: The obtained concentrations were 30.48 mg/L at 20 mL/minute, 153.65 mg/L at 40 mL/minute and 151.10 mg/L at 60 mL/minute.

- Definitive Test – Gas Saturation Method: The mean Vapour Pressure of the test item was 6.3754 mPa at 20°C (40 mL/minute) and 6.9845 mPa at 40°C (40 mL/minute)

Description of key information

The vapour pressure of the test substance is 6.38 mPa at 20°C.

Key value for chemical safety assessment

Vapour pressure:

0.006 Pa

at the temperature of:

20 °C