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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Detail of Guideline (if any) unclear from German Report. Appears similar to OECD 401 in many respects. [OECD 401 was deleted in 2002. The stepwise approach of OECD 420 was not commonly used at the time of this study.]
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
Trimethoxypropylsilane
EC Number:
213-926-7
EC Name:
Trimethoxypropylsilane
Cas Number:
1067-25-0
IUPAC Name:
trimethoxy(propyl)silane

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
4.22, 5.62, 7.50, 10.0, 13.3 g/kg bw
No. of animals per sex per dose:
10
Control animals:
no

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
7 420 mg/kg bw
Based on:
test mat.
95% CL:
6 710 - 8 210
Remarks on result:
other: Based on 14-day observation period.

Any other information on results incl. tables

Deaths within 14 days (in groups treated with 4.22, 5.62, 7.50, 10.0 or 13.3 g/kg bw): 0, 2, 3, 9, 10.

Overt toxicity was evident in all dose groups. Effects included reduced to absent spontaneous activity, reaction to external stimuli, muscle tone, reaction to pain or corneal reflex. Five rats had blood in the urine. One rat that died had dark red lungs. General condition and behaviour of most rats had returned to normal after 2 days.

Applicant's summary and conclusion

Interpretation of results:
other: CLP/EU GHS criteria are not met, no classification required according to Regulations (EC) No 1272/2008.
Conclusions:
In an acute oral toxicity study, reported in German, which was conducted using a protocol comparable to the now deleted 401, but not to GLP (reliability score 2), identified an LD50 in the male rat of 7.42 g/kg bw (95% CL 6.71-8.21).