Hexyltrimethoxysilane

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

No data

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

Detail of Guideline (if any) unclear from German Report. Appears similar to OECD 401 in many respects. [OECD 401 was deleted in 2002. The stepwise approach of OECD 420 was not commonly used at the time of this study.]

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Trimethoxypropylsilane

EC Number:

213-926-7

EC Name:

Trimethoxypropylsilane

Cas Number:

1067-25-0

IUPAC Name:

trimethoxy(propyl)silane

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

4.22, 5.62, 7.50, 10.0, 13.3 g/kg bw

No. of animals per sex per dose:

10

Control animals:

no

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

7 420 mg/kg bw

Based on:

test mat.

95% CL:

6 710 - 8 210

Remarks on result:

other: Based on 14-day observation period.

Any other information on results incl. tables

Deaths within 14 days (in groups treated with 4.22, 5.62, 7.50, 10.0 or 13.3 g/kg bw): 0, 2, 3, 9, 10.

Overt toxicity was evident in all dose groups. Effects included reduced to absent spontaneous activity, reaction to external stimuli, muscle tone, reaction to pain or corneal reflex. Five rats had blood in the urine. One rat that died had dark red lungs. General condition and behaviour of most rats had returned to normal after 2 days.

Applicant's summary and conclusion

Interpretation of results:

other: CLP/EU GHS criteria are not met, no classification required according to Regulations (EC) No 1272/2008.

Conclusions:

In an acute oral toxicity study, reported in German, which was conducted using a protocol comparable to the now deleted 401, but not to GLP (reliability score 2), identified an LD50 in the male rat of 7.42 g/kg bw (95% CL 6.71-8.21).