Registration Dossier
Registration Dossier
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EC number: 221-331-9 | CAS number: 3069-19-0
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the attached justification below and the overall justification for grouping of substances attached in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 913 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but exposure is to hydrolysis products
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 913 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but exposure is to hydrolysis products
- Basis for effect:
- growth rate
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 72-h EC50 value of >913 mg/L and NOEC of ≥913 mg/L have been determined for the effects of the test substance on growth rate of Scenedesmus subspicatus based on nominal concentrations of the substance. However it is likely that the test organisms were exposed to the hydrolysis products of the substance.
Reference
Description of key information
ErC50 (72 h) of > 913 mg/L and a NOErC (72 h) of ≥ 913 mg/L (nominal, Pseudokirchneriella subcapitata, OECD 201); based on read-across from CAS 1067-25-0
Key value for chemical safety assessment
Additional information
There are no data available on toxicity to algae for hexyl(trimethoxy)silane (CAS 3069-19-0). In accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5 “Grouping of substances and read-across” and in accordance with the read across assessment framework (RAAF, ECHA 2017) a read-across from the structurally similar substance trimethoxy(propyl)silane (CAS 1067-25-0) has been applied to support the environmental hazard assessment of hexyl(trimethoxy)silane. Details on the read across justification can be found in the attached justification in the respective target entry and in the overall justification for grouping of substances attached in IUCLID Section 13.
The study with the analogue substance trimethoxy(propyl)silane (CAS 1067-25-0) was performed according to OECD 201 (GLP). Pseudokirchneriella subcapitata was exposed to the substance up to a concentration of 913 mg/L under static conditions. Inhibition of growth was not recorded resulting in an ErC50 (72 h) of > 913 mg/L and a NOErC (72 h) of ≥ 913 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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