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EC number: 221-331-9 | CAS number: 3069-19-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral: OECD TG 401: LD50 > 3500 mg/kg bw (read across from CAS 1067 -25 -0 and 3069 -40 -7)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Remarks:
- Summary of available data used for the endpoint assessment of the target substance
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- refer to the analogue justification provided in IUCLID section 13
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 170 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: CAS 1067-25-0, ASTA Pharma, 1988
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 5 170 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: CAS 1067-25-0, ASTA Pharma, 1988
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: CAS 3069-40-7, ASTA Pharma, 1988
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 3 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: CAS 3069-40-7, ASTA Pharma, 1988
- Interpretation of results:
- other: CLP/EU GHS criteria are not met, no classification required according to Regulations (EC) No 1272/2008.
- Conclusions:
- In acute oral toxicity studies conducted in compliance with the now deleted OECD 401, but not to GLP (reliability score 2), the LD50 values for the source substances trimethoxy(propyl)silane (CAS 1067-25-0) and trimethoxy(octyl)silane (CAS 3069-40-7) were > 3500 mg/kg bw, for male and female rats, respectively. As explained in the analogue justification, it is considered that the target and the source substances are unlikely to lead to differences in acute oral toxicity potential.
Reference
The key result of an oral LD50 >= 5170 mg/kg bw found with the source substance CAS 1067 -25 -0 is supported by an older study which is used as supporting study (INBIFO, 1979) where a LD50 for male rats was 7420 mg/kg bw.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 3 500 mg/kg bw
- Quality of whole database:
- The available information comprises an adequate and reliable study (Klimisch score 2) from a source substance with similar structure and intrinsic properties. Read-across is justified based on common functional group(s) and similarities in PC/ECO/TOX properties. The selected study is thus sufficient to fulfil the standard information requirements set out in Annex VII, 8.5, in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No acute oral toxicity study on hexyl(trimethoxy)silane (CAS 3069-19-0) is available. Therefore, the hazard assessment for acute oral toxicity of the registered substance was performed based on the available data from the source substances trimethoxy(propyl)silane (CAS 1067-25-0) and trimethoxy(octyl)silane (CAS 3069 -40 -7). In accordance with Regulation (EC) No. 1907/2006 Annex XI, 1.5 “Grouping of substances and read across” and following the Read across assessment framework (RAAF, ECHA 2017) read across from analogue substances has been applied to support the human health hazard assessment of hexyl(trimethoxy)silane (CAS 3069-19-0).
The acute oral toxicity study with the source substance trimethoxy(propyl)silane (CAS 1067 -25 -0) which was conducted in compliance with GLP and according to the now deleted OECD TG 401, reports an LD50 value of ≥ 5170 mg/kg bw, for male and female rats, respectively. These values indicate low acute toxicity by the oral route of the registered substance. The most common signs of toxicity were reduced locomotion, impaired co-ordination, loss of muscle tone and loss of righting reflex (ASTA Pharma, 1988). In an additional acute oral toxicity study similar to the now deleted OECD TG 401 and not to GLP with trimethoxy(propyl)silane identified an LD50 value in the rat of 7420 mg/kg bw (INBIFO, 1979a). The results of both experiments are in agreement with the low acute oral toxicity (lethality) potential of trimethoxy(propyl)silane (CAS 1067 -25 -0).
In an acute oral toxicity study with the source substance trimethoxy(ocytyl)silane (CAS 3069 -40 -7) that was comparable to the now deleted OECD 401, but not to GLP (reliability score 2) the LD50 was at least 3500 mg/kg bw for male and female rats (ASTA Pharma AG, 1988). Following a dose of 3236 mg/kg bw there were coordination disturbances, piloerection, chromodacryorrhea, increased salivation and red nasal discharge. Following a dose of 4752 mg/kg bw there was additionally decreased muscle tone, loss of righting reflexes and increased diuresis. Individually, tremor, vocalisation on handling, lacrimation, opacity of the cornea and green discoloured urine occurred in addition. The development of toxic effects was protracted, with coordination disturbances detected after two hours, and all other symptoms from days 2-5. All symptoms disappeared by day 21 of the observation period.
In conclusion, both source substances show low acute oral toxicity with a LD50 > 3500 mg/kg bw. The same low acute oral toxicity is considered for the target substance CAS 3069 -19 -0.
Justification for classification or non-classification
Reliable data from structural analogue substances on acute oral toxicity indicates that the registered substance does not meet the criteria for classification according to Regulation (EC) No. 1272/2008, and the available data are therefore conclusive but not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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