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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Please refer to the attached justification below and the overall justification for grouping of substances attached in IUCLID Section 13.
Reason / purpose for cross-reference:
read-across source
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 816 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
but exposure is to hydrolysis products
Basis for effect:
mobility
Duration:
48 h
Dose descriptor:
NOEC
Effect conc.:
>= 816 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
but exposure is to hydrolysis products
Basis for effect:
mobility

Description of key information

EC50 (48 h) >816 mg/L (nominal, Daphnia magna, OECD 202); based on read-across from CAS 1067-25-0

Key value for chemical safety assessment

Additional information

There are no data available on short-term toxicity to aquatic invertebrates for hexyl(trimethoxy)silane (CAS 3069-19-0). In accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5 “Grouping of substances and read-across” and in accordance with the read across assessment framework (RAAF, ECHA 2017) a read-across from the structurally similar substance trimethoxy(propyl)silane (CAS 1067-25-0) has been applied to support the environmental hazard assessment of hexyl(trimethoxy)silane. Details on the read across justification can be found in the attached justification in the respective target entry and in the overall justification for grouping of substances attached in IUCLID Section 13.

The study with the analogue substance trimethoxy(propyl)silane (CAS 1067-25-0) was performed according to EU Method C.2 (GLP). Daphnia magna was exposed to the substance up to a concentration of 816 mg/L under static conditions. After 48 h no immobilization of Daphnia magna was recorded resulting in an EC50 (48 h) >816 mg/L (nominal).